Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.
Identifieur interne : 000467 ( Main/Exploration ); précédent : 000466; suivant : 000468Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.
Auteurs : Syed Faraz Ahmed [République populaire de Chine] ; Ahmed A. Quadeer [République populaire de Chine] ; Matthew R. Mckay [République populaire de Chine]Source :
- Viruses [ 1999-4915 ] ; 2020.
Descripteurs français
- KwdFr :
- Cartographie épitopique, Déterminants antigéniques des lymphocytes B (génétique), Déterminants antigéniques des lymphocytes B (immunologie), Déterminants antigéniques des lymphocytes T (génétique), Déterminants antigéniques des lymphocytes T (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Génome viral, Humains, Infections à coronavirus (), Phylogénie, Pneumopathie virale (), Protéines nucléocapside (génétique), Protéines nucléocapside (immunologie), Structure tertiaire des protéines, Vaccins antiviraux (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Déterminants antigéniques des lymphocytes B, Déterminants antigéniques des lymphocytes T, Glycoprotéine de spicule des coronavirus, Protéines nucléocapside, Virus du SRAS.
- immunologie : Déterminants antigéniques des lymphocytes B, Déterminants antigéniques des lymphocytes T, Glycoprotéine de spicule des coronavirus, Protéines nucléocapside, Vaccins antiviraux, Virus du SRAS.
- Cartographie épitopique, Génome viral, Humains, Infections à coronavirus, Phylogénie, Pneumopathie virale, Structure tertiaire des protéines.
English descriptors
- KwdEn :
- Betacoronavirus (genetics), Betacoronavirus (immunology), Coronavirus Infections (prevention & control), Epitope Mapping, Epitopes, B-Lymphocyte (genetics), Epitopes, B-Lymphocyte (immunology), Epitopes, T-Lymphocyte (genetics), Epitopes, T-Lymphocyte (immunology), Genome, Viral, Humans, Nucleocapsid Proteins (genetics), Nucleocapsid Proteins (immunology), Phylogeny, Pneumonia, Viral (prevention & control), Protein Structure, Tertiary, SARS Virus (genetics), SARS Virus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : Epitopes, B-Lymphocyte, Epitopes, T-Lymphocyte, Nucleocapsid Proteins, Spike Glycoprotein, Coronavirus.
- genetics : Betacoronavirus, SARS Virus.
- immunology : Betacoronavirus, Epitopes, B-Lymphocyte, Epitopes, T-Lymphocyte, Nucleocapsid Proteins, SARS Virus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- prevention & control : Coronavirus Infections, Pneumonia, Viral.
- Epitope Mapping, Genome, Viral, Humans, Phylogeny, Protein Structure, Tertiary.
Abstract
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent need to better understand this new virus and to develop ways to control its spread. In this study, we sought to gain insights for vaccine design against SARS-CoV-2 by considering the high genetic similarity between SARS-CoV-2 and SARS-CoV, which caused the outbreak in 2003, and leveraging existing immunological studies of SARS-CoV. By screening the experimentally-determined SARS-CoV-derived B cell and T cell epitopes in the immunogenic structural proteins of SARS-CoV, we identified a set of B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins that map identically to SARS-CoV-2 proteins. As no mutation has been observed in these identified epitopes among the 120 available SARS-CoV-2 sequences (as of 21 February 2020), immune targeting of these epitopes may potentially offer protection against this novel virus. For the T cell epitopes, we performed a population coverage analysis of the associated MHC alleles and proposed a set of epitopes that is estimated to provide broad coverage globally, as well as in China. Our findings provide a screened set of epitopes that can help guide experimental efforts towards the development of vaccines against SARS-CoV-2.
DOI: 10.3390/v12030254
PubMed: 32106567
Affiliations:
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Le document en format XML
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Quadeer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Mckay, Matthew R" sort="Mckay, Matthew R" uniqKey="Mckay M" first="Matthew R" last="Mckay">Matthew R. Mckay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Epitope Mapping</term><term>Epitopes, B-Lymphocyte (genetics)</term><term>Epitopes, B-Lymphocyte (immunology)</term><term>Epitopes, T-Lymphocyte (genetics)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Genome, Viral</term><term>Humans</term><term>Nucleocapsid Proteins (genetics)</term><term>Nucleocapsid Proteins (immunology)</term><term>Phylogeny</term><term>Pneumonia, Viral (prevention & control)</term><term>Protein Structure, Tertiary</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cartographie épitopique</term><term>Déterminants antigéniques des lymphocytes B (génétique)</term><term>Déterminants antigéniques des lymphocytes B (immunologie)</term><term>Déterminants antigéniques des lymphocytes T (génétique)</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Génome viral</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Phylogénie</term><term>Pneumopathie virale ()</term><term>Protéines nucléocapside (génétique)</term><term>Protéines nucléocapside (immunologie)</term><term>Structure tertiaire des protéines</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes, B-Lymphocyte</term><term>Epitopes, T-Lymphocyte</term><term>Nucleocapsid Proteins</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes B</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine de spicule des coronavirus</term><term>Protéines nucléocapside</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes B</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine de spicule des coronavirus</term><term>Protéines nucléocapside</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term><term>Epitopes, B-Lymphocyte</term><term>Epitopes, T-Lymphocyte</term><term>Nucleocapsid Proteins</term><term>SARS Virus</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Epitope Mapping</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>Protein Structure, Tertiary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie épitopique</term><term>Génome viral</term><term>Humains</term><term>Infections à coronavirus</term><term>Phylogénie</term><term>Pneumopathie virale</term><term>Structure tertiaire des protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent need to better understand this new virus and to develop ways to control its spread. In this study, we sought to gain insights for vaccine design against SARS-CoV-2 by considering the high genetic similarity between SARS-CoV-2 and SARS-CoV, which caused the outbreak in 2003, and leveraging existing immunological studies of SARS-CoV. By screening the experimentally-determined SARS-CoV-derived B cell and T cell epitopes in the immunogenic structural proteins of SARS-CoV, we identified a set of B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins that map identically to SARS-CoV-2 proteins. As no mutation has been observed in these identified epitopes among the 120 available SARS-CoV-2 sequences (as of 21 February 2020), immune targeting of these epitopes may potentially offer protection against this novel virus. For the T cell epitopes, we performed a population coverage analysis of the associated MHC alleles and proposed a set of epitopes that is estimated to provide broad coverage globally, as well as in China. Our findings provide a screened set of epitopes that can help guide experimental efforts towards the development of vaccines against SARS-CoV-2.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ahmed, Syed Faraz" sort="Ahmed, Syed Faraz" uniqKey="Ahmed S" first="Syed Faraz" last="Ahmed">Syed Faraz Ahmed</name></noRegion><name sortKey="Mckay, Matthew R" sort="Mckay, Matthew R" uniqKey="Mckay M" first="Matthew R" last="Mckay">Matthew R. Mckay</name><name sortKey="Quadeer, Ahmed A" sort="Quadeer, Ahmed A" uniqKey="Quadeer A" first="Ahmed A" last="Quadeer">Ahmed A. 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